Amy Adams and Isla Fisher
They're Hollywood's most adorable red heads, renowned for playing the helplessly endearing damsel in films like Enchanted and Confessions of a Shopaholic, but can you tell Amy Adams and Isla Fisher apart? Isla has used their similarities to her advantage. "If [Confessions] is a hit, it was Isla Fisher in the movie," she joked prior to the release of the 2009 rom-com. "And if it doesn't work out, it was Amy Adams."